NIK overexpression amplifies, whereas ablation of its TRAF3-binding domain replaces BAFF:BAFF-R-mediated survival signals in B cells
نویسندگان
چکیده
منابع مشابه
NIK overexpression amplifies, whereas ablation of its TRAF3-binding domain replaces BAFF:BAFF-R-mediated survival signals in B cells.
BAFF-R-dependent activation of the alternative NF-kappaB pathway plays an essential role in mature B cell survival. Mutations leading to overexpression of NIK and deletion of the TRAF3 gene are implicated in human multiple myeloma. We show that overexpression of NIK in mouse B lymphocytes amplifies alternative NF-kappaB activation and peripheral B cell numbers in a BAFF-R-dependent manner, wher...
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The Lymphotoxinreceptor (LT R) activates the NFB2 transcription factors, p100 and RelB, by regulating the NFB-inducing kinase (NIK). Constitutive proteosomal degradation of NIK limits NFB activation in unstimulated cells by the ubiquitin:NIK E3 ligase comprised of subunits TNFR-associated factors (TRAF)3, TRAF2 and cellular inhibitor of apoptosis (cIAP). However, the mechanism releasing NIK fro...
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has been approved by the Examining Committee for the thesis requirement for the Doctor of Philosophy degree in Immunology at the May 2015 graduation. ii To my family and friends, thank you for the endless support iii ACKNOWLEDGEMENTS First and foremost, I would like to thank my mentor, Dr. Gail Bishop, for her mentorship and support for the past five years. Gail provided me with excellent guida...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2008
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0805186105